Styryl-based compounds as potential in vivo imaging agents for beta-amyloid plaques
SCIE
SCOPUS
- Title
- Styryl-based compounds as potential in vivo imaging agents for beta-amyloid plaques
- Authors
- Li, Qian; Min, Jaeki; Ahn, Young-Hoon; Namm, Joshua; Kim, Eun Min; Lui, Rowena; Kim, Hye Yun; Ji, Yong; Wu, Hueizhi; Wisniewski, Thomas; Chang, Young-Tae
- Date Issued
- 2007-09
- Publisher
- WILEY-V C H VERLAG GMBH
- Abstract
- A group of styryl-based neutral compounds has been synthesized in this study for potential use as in vivo imaging agents for beta-amyloid plaques. Of 56 candidates, 14 compounds were found to label beta-amyloid plaques well on Alzheimer's disease (AD) human brain sections in vitro. The binding affinity to beta-amyloid fibrils was then determined by measuring the change in fluorescence intensity. Interestingly, we found that a class of quinaldine-styryl scaffold compounds displays specific binding to beta-amyloid fibrils. A representative compound, STB-8, was used in ex vivo and in vivo imaging experiments on an AD transgenic mouse model and demonstrated excellent blood-brain barrier (BBB) permeability and specific staining of the AD beta-amyloid plaques.
- Keywords
- POSITRON-EMISSION-TOMOGRAPHY; ALZHEIMERS-DISEASE; CONGO-RED; BENZOFURAN DERIVATIVES; PEPTIDE FIBRILS; BINDING-SITES; CHRYSAMINE-G; BRAIN; DEPOSITS; PROBES
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50253
- DOI
- 10.1002/cbic.200700154
- ISSN
- 1439-4227
- Article Type
- Article
- Citation
- CHEMBIOCHEM, vol. 8, no. 14, page. 1679 - 1687, 2007-09
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- There are no files associated with this item.
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