Piezoelectric Nanoparticle-Assisted Wireless Neuronal Stimulation
SCIE
SCOPUS
- Title
- Piezoelectric Nanoparticle-Assisted Wireless Neuronal Stimulation
- Authors
- Marino, Attilio; Arai, Satoshi; Hou, Yanyan; Sinibaldi, Edoardo; Pellegrino, Mario; Chang, Young-Tae; Mazzolai, Barbara; Mattoli, Virgilio; Suzuki, Madoka; Ciofani, Gianni
- Date Issued
- 2015-07
- Publisher
- AMER CHEMICAL SOC
- Abstract
- Tetragonal barium titanate nanoparticles (BTNPs) have been exploited as nanotransducers owing to their piezoelectric properties, in order to provide indirect electrical stimulation to SH-SY5Y neuron-like cells. Following application of ultrasounds to cells treated with BTNPs, fluorescence imaging of ion dynamics revealed that the synergic stimulation is able to elicit a significant cellular response in terms of calcium and sodium fluxes; moreover, tests with appropriate blockers demonstrated that voltage-gated membrane channels are activated. The hypothesis of piezoelectric stimulation of neuron-like cells was supported by lack of cellular response in the presence of cubic nonpiezoelectric BTNPs, and further corroborated by a simple electroelastic model of a BTNP subjected to ultrasounds, according to which the generated voltage is compatible with the values required for the activation of voltage-sensitive channels.
- Keywords
- BARIUM-TITANATE NANOPARTICLES; GATED ION CHANNELS; NEURITE OUTGROWTH; BRAIN-STIMULATION; ELECTROSPUN SCAFFOLDS; ENDOPLASMIC-RETICULUM; CATION CHANNELS; LEECH NEURONS; TEMPERATURE; ULTRASOUND
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50279
- DOI
- 10.1021/acsnano.5b03162
- ISSN
- 1936-0851
- Article Type
- Article
- Citation
- ACS NANO, vol. 9, no. 7, page. 7678 - 7689, 2015-07
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- There are no files associated with this item.
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