New insight of squaraine-based biocompatible surface-enhanced Raman scattering nanotag for cancer-cell imaging
SCIE
SCOPUS
- Title
- New insight of squaraine-based biocompatible surface-enhanced Raman scattering nanotag for cancer-cell imaging
- Authors
- Ramya, A. N.; Samanta, Animesh; Nisha, N.; Chang, Young-Tae; Maiti, Kaustabh Kumar
- Date Issued
- 2015-02
- Publisher
- FUTURE MEDICINE LTD
- Abstract
- Aim: Development of highly sensitive diagnostic nanoprobe for cancer imaging based on surface-enhanced Raman scattering (SERS) platform. Materials & methods: Synthesis of novel squaraine dyes as a Raman signature molecule denoted as lipoic-squaraine-lipoic (LSL), propyl-squaraine-lipoic (PSL) and propyl-squaraine-propyl (PSP). The SERS-nanotag constructed with a Raman signature molecule which is attached on gold nanoparticle and further encapsulated with heterofunctionalized PEG. Antibody conjugation with best SERS-nanotag for target specific recognition. Results: SERS nanotag Au-LSL-PEG showed significant signal intensity and remarkable stability. Anti-EGF receptor and Her2-conjugated Au-LSL-PEG-nanotag were successfully applied for selective recognition of cancer cells like A549, OSCC and MCF7. Conclusion: The newly developed SERS-nanotag Au-LSL-PEG serves as a valuable tool for diagnostic detection of cancer cells, and may find potential applications for cancer screening in real patient samples.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50393
- DOI
- 10.2217/nnm.14.125
- ISSN
- 1743-5889
- Article Type
- Article
- Citation
- NANOMEDICINE, vol. 10, no. 4, page. 561 - 571, 2015-02
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