Plasmacytoid dendritic cells contribute to the protective immunity induced by intranasal treatment with fc-fused interleukin-7 against lethal influenza virus infection
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- Title
- Plasmacytoid dendritic cells contribute to the protective immunity induced by intranasal treatment with fc-fused interleukin-7 against lethal influenza virus infection
- Authors
- Kang Moon Cheol; Park Han Wook; Choi Dong-Hoon; Choi Young Woo; Park Yunji; Sung Young Chul; Lee Seung-Woo
- Date Issued
- 2017-10
- Publisher
- 대한면역학회
- Abstract
- Developing a novel vaccine that can be applied against multiple strains of influenza virus is of utmost importance to human health. Previously, we demonstrated that the intranasal introduction of Fc-fused IL-7 (IL-7-mFc), a long-acting cytokine fusion protein, confers long-lasting prophylaxis against multiple strains of influenza A virus (IAV) by inducing the development of lung-resident memory-like T cells, called TRM-like cells. Here, we further investigated the mechanisms of IL-7-mFc-mediated protective immunity to IAVs. First, we found that IL-7-mFc treatment augments the accumulation of pulmonary T cells in 2 ways: recruiting blood circulating T cells into the lung and expanding T cells at the lung parenchyma. Second, the blockade of T cell migration from the lymph nodes (LNs) with FTY720 treatment was not required for mounting the protective immunity to IAV with IL-7-mFc, suggesting a more important role of IL-7 in T cells in the lungs. Third, IL-7-mFc treatment also recruited various innate immune cells into the lungs. Among these cells, plasmacytoid dendritic cells (pDCs) play an important role in IL-7-mFc-mediated protective immunity through reducing the immunopathology and increasing IAV-specific cytotoxic T lymphocyte (CTL) responses. In summary, our results show that intranasal treatment with IL-7-mFc modulates pulmonary immune responses to IAV, affecting both innate and adaptive immune cells. ? 2017. The Korean Association of Immunologists.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50863
- DOI
- 10.4110/in.2017.17.5.343
- ISSN
- 1598-2629
- Article Type
- Article
- Citation
- Immune Network, vol. 17, no. 5, page. 343 - 351, 2017-10
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