DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Yun | - |
dc.contributor.author | Shen, Jinbo | - |
dc.contributor.author | Lee, Myoung Hui | - |
dc.contributor.author | Geem, Kyoung Rok | - |
dc.contributor.author | Jiang, Liwen | - |
dc.contributor.author | Hwang, Inhwan | - |
dc.date.accessioned | 2018-06-15T05:53:34Z | - |
dc.date.available | 2018-06-15T05:53:34Z | - |
dc.date.created | 2018-03-22 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/50954 | - |
dc.description.abstract | Protein trafficking is a fundamental mechanism of subcellular organization and contributes to organellar biogenesis. AtCAP2 is an Arabidopsis homolog of the Mesembryanthemum crystallinum calcium-dependent protein kinase 1 adaptor protein 2 (McCAP2), a member of the syntaxin superfamily. Here, we show that AtCAP2 plays an important role in the conversion to the lytic vacuole (LV) during early plant development. The AtCAP2 loss-of-function mutant atcap2-1 displayed delays in protein storage vacuole (PSV) protein degradation, PSV fusion, LV acidification, and biosynthesis of several vacuolar proteins during germination. At the mature stage, atcap2-1 plants accumulated vacuolar proteins in the pre-vacuolar compartment (PVC) instead of the LV. In wild-type plants, AtCAP2 localizes to the PVC as a peripheral membrane protein and in the PVC compartment recruits glyceraldehyde-3-phosphate dehydrogenase C2 (GAPC2) to the PVC. We propose that AtCAP2 contributes to LV biogenesis during early plant development by supporting the trafficking of specific proteins involved in the PSV-to-LV transition and LV acidification during early stages of plant development. | - |
dc.language | English | - |
dc.publisher | National Academy of Sciences | - |
dc.relation.isPartOf | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.title | AtCAP2 is crucial for lytic vacuole biogenesis during germination by positively regulating vacuolar protein trafficking | - |
dc.type | Article | - |
dc.identifier.doi | 10.1073/pnas.1717204115 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Proceedings of the National Academy of Sciences of the United States of America, v.115, no.7, pp.E1675 - E1683 | - |
dc.identifier.wosid | 000424876000041 | - |
dc.date.tcdate | 2018-03-23 | - |
dc.citation.endPage | E1683 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | E1675 | - |
dc.citation.title | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.citation.volume | 115 | - |
dc.contributor.affiliatedAuthor | Kwon, Yun | - |
dc.contributor.affiliatedAuthor | Geem, Kyoung Rok | - |
dc.contributor.affiliatedAuthor | Hwang, Inhwan | - |
dc.identifier.scopusid | 2-s2.0-85042016590 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | EARLY SECRETORY PATHWAY | - |
dc.subject.keywordPlus | SOLUBLE CARGO PROTEINS | - |
dc.subject.keywordPlus | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM | - |
dc.subject.keywordPlus | ARABIDOPSIS-THALIANA | - |
dc.subject.keywordPlus | PHOSPHATIDIC-ACID | - |
dc.subject.keywordPlus | SORTING RECEPTOR | - |
dc.subject.keywordPlus | PLANT-CELLS | - |
dc.subject.keywordPlus | INTRACELLULAR TRAFFICKING | - |
dc.subject.keywordPlus | VESICULAR TRANSPORT | - |
dc.subject.keywordAuthor | lytic vacuole transition | - |
dc.subject.keywordAuthor | vacuolar pH | - |
dc.subject.keywordAuthor | vacuolar trafficking | - |
dc.subject.keywordAuthor | intracellular trafficking | - |
dc.subject.keywordAuthor | GAPC2 trafficking | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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