Stimulus-specific combinatorial functionality of neuronal c-fos enhancers
SCIE
SCOPUS
- Title
- Stimulus-specific combinatorial functionality of neuronal c-fos enhancers
- Authors
- KIM, TAE KYUNG
- Date Issued
- 2016-01
- Publisher
- NATURE PUBLISHING GROUP
- Abstract
- The c-fos gene (also known as Fos) is induced by a broad range of stimuli and is a reliable marker for neural activity. Its induction mechanism and available reporter mouse lines are based exclusively on c-fos promoter activity. Here we demonstrate that multiple enhancers surrounding the c-fos gene are crucial for ensuring robust c-fos response to various stimuli. Membrane depolarization, brain-derived neurotrophic factor (BDNF) and forskolin activate distinct subsets of the enhancers to induce c-fos transcription in neurons, suggesting that stimulus-specific combinatorial activation of multiple enhancers underlies the broad inducibility of the c-fos gene. Accordingly, the functional requirement of key transcription factors varies depending on the type of stimulation. Combinatorial enhancer activation also occurs in the brain. Providing a comprehensive picture of the c-fos induction mechanism beyond the minimal promoter, our study should help in understanding the physiological nature of c-fos induction in relation to neural activity and plasticity.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/94310
- DOI
- 10.1038/nn.4170
- ISSN
- 1097-6256
- Article Type
- Article
- Citation
- NATURE NEUROSCIENCE, vol. 19, no. 1, page. 75 - +, 2016-01
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