DC Field | Value | Language |
---|---|---|
dc.contributor.author | KIM, TAE KYUNG | - |
dc.date.accessioned | 2018-12-04T01:54:54Z | - |
dc.date.available | 2018-12-04T01:54:54Z | - |
dc.date.created | 2018-11-21 | - |
dc.date.issued | 2014-12-04 | - |
dc.identifier.issn | 1934-5909 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/94315 | - |
dc.description.abstract | LIN28-mediated processing of the microRNA (miRNA) let-7 has emerged as a multilevel program that controls self-renewal in embryonic stem cells. LIN28A is believed to act primarily in the cytoplasm together with TUT4/7 to prevent final maturation of let-7 by Dicer, whereas LIN28B has been suggested to preferentially act on nuclear processing of let-7. Here, we find that SET7/9 monomethylation in a putative nucleolar localization region of LIN28A increases its nuclear retention and protein stability. In the nucleoli of human embryonic stem cells, methylated LIN28A sequesters pri-let-7 and blocks its processing independently of TUT4/7. The nuclear form of LIN28A regulates transcriptional changes in MYC-pathway targets, thereby maintaining stemness programs and inhibiting expression of early lineage-specific markers. These findings provide insight into the molecular mechanism underlying the post-translational methylation of nuclear LIN28A and its ability to modulate pluripotency by repressing let-7 miRNA expression in human embryonic stem cells. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.relation.isPartOf | Cell Stem Cell | - |
dc.title | SET7/9 methylation of the pluripotency factor LIN28A is a nucleolar localization mechanism that blocks let-7 biogenesis in human ESCs. | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.stem.2014.10.016 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Cell Stem Cell, v.15, no.6, pp.735 - 749 | - |
dc.identifier.wosid | 000347174300012 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 749 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 735 | - |
dc.citation.title | Cell Stem Cell | - |
dc.citation.volume | 15 | - |
dc.contributor.affiliatedAuthor | KIM, TAE KYUNG | - |
dc.identifier.scopusid | 2-s2.0-84919426973 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 25 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MICRORNA BIOGENESIS | - |
dc.subject.keywordPlus | LYSINE METHYLATION | - |
dc.subject.keywordPlus | MESSENGER-RNAS | - |
dc.subject.keywordPlus | SELF-RENEWAL | - |
dc.subject.keywordPlus | PRE-MICRORNA | - |
dc.subject.keywordPlus | DNA-BINDING | - |
dc.subject.keywordPlus | LIN-28 | - |
dc.subject.keywordPlus | METHYLTRANSFERASE | - |
dc.subject.keywordPlus | REGULATOR | - |
dc.subject.keywordPlus | STABILITY | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
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