DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yun Seop | - |
dc.contributor.author | Sung, Dong Kyung | - |
dc.contributor.author | Kong, Won Ho | - |
dc.contributor.author | Kim, Hyemin | - |
dc.contributor.author | Hahn, Sei Kwang | - |
dc.date.accessioned | 2019-03-07T01:13:54Z | - |
dc.date.available | 2019-03-07T01:13:54Z | - |
dc.date.created | 2018-06-12 | - |
dc.date.issued | 2018-05 | - |
dc.identifier.issn | 2047-4830 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/94978 | - |
dc.description.abstract | The proteolytic microenvironment in the wound area reduces the stability and the half-life of growth factors in vivo, making difficult the topical delivery of growth factors. Here, epidermal growth factor (EGF) was conjugated to hyaluronate (HA) to improve the long-term stability against enzymatic degradation and the therapeutic effect by enhancing the biological interaction with HA receptors on skin cells. After the synthesis of HA-EGF conjugates, they were incorporated into a patch-type formulation for the facile topical application and sustained release of EGF. According to ELISA, the HA-EGF conjugates showed a long-term stability compared with native EGF. Furthermore, HA-EGF conjugates appeared to interact with skin cells through two types of HA and EGF receptors, resulting in a synergistically improved healing effect. Taken together, we could confirm the feasibility of HA-EGF conjugates for the transdermal treatment of chronic wounds. | - |
dc.language | English | - |
dc.publisher | Royal Society of Chemistry | - |
dc.relation.isPartOf | Biomaterials Science | - |
dc.title | Synergistic Effects of Hyaluronate - Epidermal Growth Factor Conjugate Patch on Chronic Wound Healing | - |
dc.type | Article | - |
dc.identifier.doi | 10.1039/c8bm00079d | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Biomaterials Science, v.6, no.5, pp.1020 - 1030 | - |
dc.identifier.wosid | 000431111600010 | - |
dc.citation.endPage | 1030 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1020 | - |
dc.citation.title | Biomaterials Science | - |
dc.citation.volume | 6 | - |
dc.contributor.affiliatedAuthor | Hahn, Sei Kwang | - |
dc.identifier.scopusid | 2-s2.0-85046287516 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MULTIVALENT SONIC HEDGEHOG | - |
dc.subject.keywordPlus | DEXTRIN-RHEGF | - |
dc.subject.keywordPlus | EXTRACELLULAR-MATRIX | - |
dc.subject.keywordPlus | MOLECULAR-WEIGHT | - |
dc.subject.keywordPlus | FULL-THICKNESS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | PEGYLATION | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Materials Science | - |
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