Synergistic Effects of Hyaluronate - Epidermal Growth Factor Conjugate Patch on Chronic Wound Healing
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SCOPUS
- Title
- Synergistic Effects of Hyaluronate - Epidermal Growth Factor Conjugate Patch on Chronic Wound Healing
- Authors
- Kim, Yun Seop; Sung, Dong Kyung; Kong, Won Ho; Kim, Hyemin; Hahn, Sei Kwang
- Date Issued
- 2018-05
- Publisher
- Royal Society of Chemistry
- Abstract
- The proteolytic microenvironment in the wound area reduces the stability and the half-life of growth factors in vivo, making difficult the topical delivery of growth factors. Here, epidermal growth factor (EGF) was conjugated to hyaluronate (HA) to improve the long-term stability against enzymatic degradation and the therapeutic effect by enhancing the biological interaction with HA receptors on skin cells. After the synthesis of HA-EGF conjugates, they were incorporated into a patch-type formulation for the facile topical application and sustained release of EGF. According to ELISA, the HA-EGF conjugates showed a long-term stability compared with native EGF. Furthermore, HA-EGF conjugates appeared to interact with skin cells through two types of HA and EGF receptors, resulting in a synergistically improved healing effect. Taken together, we could confirm the feasibility of HA-EGF conjugates for the transdermal treatment of chronic wounds.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/94978
- DOI
- 10.1039/c8bm00079d
- ISSN
- 2047-4830
- Article Type
- Article
- Citation
- Biomaterials Science, vol. 6, no. 5, page. 1020 - 1030, 2018-05
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